E4632
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E4632
Sigma
Econazole nitrate salt
| Synonym: | 1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole |
| CAS Number: | 24169-02-6 |
| Linear Formula: | C18H15Cl3N2O · HNO3 |
| Molecular Weight: | 444.70 |
| EC Number: | 246-053-5 |
| MDL number: | MFCD00058160 |
| PubChem Substance ID: | 24894567 |
Description
| Biochem/physiol Actions | Econazole is an azole-based antifungal similar to ketoconazole. Its mechanism of action may involve inhibition of membrane enzymes, including cytochrome P450,1 and lipid biosynthesis.2 The bactericidal and inhibitory effects of several azole antifungal compounds, including econazole, against Mycobacterium smegmatis has been investigated.3 |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-36/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | NI4450000 |
References
| Cited Reference | 1. McLean, K.J., et al., Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes. Microbiology 148, 2937-49, (2002) Abstract |
| 2. Ghannoum, M.A., and Rice, L.B., Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin. Microbiol. Reviews 12, 501-17, (1999) | |
| 3. Jackson, C.J., et al., Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis. FEMS Microbiol. Lett. 192, 159-162, (2000) Abstract | |
| reference | Heel, R.C., et al., Econazole: a review of its antifungal activity and therapeutic efficacy. Drugs 16, 177-201, (1978) Abstract |
